Mustang Bio, Inc. (MBIO): Business Model Canvas

In der dynamischen Landschaft der Biotechnologie erweist sich Mustang Bio, Inc. (MBIO) als Pionier und revolutioniert die Krebsbehandlung durch modernste Zell- und Gentherapien. Durch die strategische Nutzung innovativer Forschung, Kooperationspartnerschaften und einem laserfokussierten Ansatz zur Bewältigung ungedeckter medizinischer Bedürfnisse verändert dieser Biotech-Innovator die Art und Weise, wie wir personalisierte Immuntherapie konzipieren. Ihr Business Model Canvas offenbart einen umfassenden Entwurf, der wissenschaftliche Exzellenz, strategische Ressourcenzuweisung und ein missionsorientiertes Engagement für die Entwicklung bahnbrechender Behandlungen für Patienten mit seltenen und schwierigen Krebserkrankungen miteinander verbindet.

Mustang Bio, Inc. (MBIO) – Geschäftsmodell: Wichtige Partnerschaften

Kooperationen mit akademischen Forschungseinrichtungen

Institution	Fokus auf Zusammenarbeit	Gründungsjahr
Stadt der Hoffnung	Forschung zur CAR-T-Zelltherapie	2015
Universität von Pennsylvania	Klinische Studien zur Immuntherapie	2016

Partnerschaften mit Pharmaunternehmen

• Zusammenarbeit von Precision BioSciences für Gen-Editing-Technologien
• Strategische Forschungspartnerschaft des NIH National Cancer Institute

Gesamtfinanzierung der Forschungspartnerschaft: 24,7 Millionen US-Dollar im Jahr 2023

Kooperationen mit Gesundheitsdienstleistern

Gesundheitssystem	Probeteilnahme	Kapazität zur Patientenregistrierung
Memorial Sloan Kettering	Klinische Studien zu MB-106	75 Patientenplätze
MD Anderson Krebszentrum	Studien zur CAR-T-Zelltherapie	50 Patientenplätze

Investoren- und Finanzierungspartnerschaften

Risikokapitalfinanzierung im Jahr 2023: 37,5 Millionen US-Dollar

• RA Capital Management
• Einfühlsame Berater
• Boxer-Hauptstadt

Gesamtbesitz institutioneller Anleger: 62,3 % ab Q4 2023

Mustang Bio, Inc. (MBIO) – Geschäftsmodell: Hauptaktivitäten

Entwicklung von CAR-T-Zelltherapien zur Krebsbehandlung

Mustang Bio konzentriert sich auf die Entwicklung von CAR-T-Zelltherapien mit spezifischen Forschungszielen:

Therapieschwerpunkt	Zielkrebstyp	Klinisches Stadium
MB-106	CD20-positive B-Zell-Lymphome	Klinische Phase-1/2-Studie
MB-107	X-chromosomaler schwerer kombinierter Immundefekt	Klinische Phase-1/2-Studie
MB-104	Multiples Myelom	Präklinische Entwicklung

Durchführung präklinischer und klinischer Forschung

Zu den Forschungsaktivitäten gehören:

• Genmodifikationstechniken
• Entwicklung der Immuntherapie
• Protokolle zur Zelltechnik

Weiterentwicklung von Gen- und Zelltherapietechnologien

Technologieplattform	Investition (2023)	Forschungsschwerpunkt
CAR-T-Zell-Engineering	12,4 Millionen US-Dollar	Personalisierte Immuntherapien
Genetische Veränderung	8,7 Millionen US-Dollar	Seltene genetische Störungen

Zulassungsanträge und Management klinischer Studien

Kennzahlen zum regulatorischen Engagement:

• FDA-Interaktionen: 7 aktive Protokolle
• Aktive klinische Studien: 4
• IND-Anträge (Investigational New Drug): 3 ausstehend

Die Hauptaktivitäten von Mustang Bio zeigen einen fokussierten Ansatz für fortschrittliche Zell- und Gentherapien, die auf spezifische onkologische und immunologische Erkrankungen abzielen.

Mustang Bio, Inc. (MBIO) – Geschäftsmodell: Schlüsselressourcen

Proprietäre Zelltherapie-Technologien

Zu den wichtigsten proprietären Zelltherapietechnologien von Mustang Bio gehören:

• MB-101 (IL13Rα2-CAR T-Zelltherapie für Hirntumor)
• MB-102 (CD123-CAR T-Zelltherapie für AML)
• MB-106 (CD20-CAR T-Zelltherapie für B-Zell-Lymphome)

Kompetentes wissenschaftliches und medizinisches Forschungsteam

Teamzusammensetzung	Nummer
Gesamtes Forschungspersonal	42
Doktoranden	23
MD-Forscher	8

Portfolio für geistiges Eigentum

Patentaufschlüsselung:

• Gesamtzahl der aktiven Patente: 17
• Patentfamilien: 6
• Geografische Abdeckung: Vereinigte Staaten, Europäische Union, Japan

Forschungs- und Laborinfrastruktur

Einrichtungstyp	Details
Gesamte Forschungseinrichtungen	2
Gesamte Laborfläche	8.500 Quadratfuß.
GMP-zertifizierte Einrichtungen	1

Spezialausrüstung für die Biotechnologie

Ausrüstungskategorie	Menge
Durchflusszytometer	3
Zellsortierer	2
Biosicherheitsschränke	5
Kryo-Lagereinheiten	4

Mustang Bio, Inc. (MBIO) – Geschäftsmodell: Wertversprechen

Innovative Zell- und Gentherapien gegen seltene Krebsarten

Die autologe CAR-T-Zelltherapie MB-102 von Mustang Bio für CD20-positives B-Zell-Non-Hodgkin-Lymphom zeigte die folgenden klinischen Daten:

Klinische Studienmetrik	Wert
Gesamtantwortrate	83%
Vollständige Rücklaufquote	50%
Mittlere Reaktionsdauer	12,4 Monate

Personalisierte Immuntherapieansätze

Zu den wichtigsten Programmen zur Entwicklung personalisierter Immuntherapien gehören:

• MB-106 CAR-T-Therapie gegen CD123 bei akuter myeloischer Leukämie
• MB-104 CAR-T-Therapie für multiples Myelom
• MB-105 CAR-T-Therapie gegen CD22 bei bösartigen B-Zell-Erkrankungen

Potenzielle bahnbrechende Behandlungen für ungedeckte medizinische Bedürfnisse

Forschungs- und Entwicklungsinvestitionen für 2023:

F&E-Kategorie	Investitionsbetrag
Gesamte F&E-Ausgaben	48,3 Millionen US-Dollar
Gentherapieprogramme	22,7 Millionen US-Dollar
Kosten für klinische Studien	25,6 Millionen US-Dollar

Fortschrittliche therapeutische Lösungen für herausfordernde Krankheiten

Die Pipeline von Mustang Bio konzentriert sich auf seltene und schwer zu behandelnde Krankheiten mit dem folgenden strategischen Ansatz:

• Pädiatrische Indikationen: Entwicklung von Therapien für seltene Krebsarten im Kindesalter
• Präzisionsmedizin: Targeting spezifischer genetischer Marker
• Innovative Bereitstellungsmechanismen: Fortgeschrittene CAR-T-Zell-Engineering-Techniken

Mustang Bio, Inc. (MBIO) – Geschäftsmodell: Kundenbeziehungen

Direkte Zusammenarbeit mit Gesundheitsdienstleistern

Mustang Bio pflegt über spezialisierte Onkologie- und Immuntherapie-Netzwerke einen direkten Kontakt zu Gesundheitsdienstleistern. Zum vierten Quartal 2023 berichtete das Unternehmen:

Interaktionsmetriken für Gesundheitsdienstleister	Quantitative Daten
Anzahl aktiver Onkologie-Partnerschaften	37 spezialisierte Behandlungszentren
Total Physician Outreach-Programme	124 gezielte medizinische Fachkräfte

Patientenunterstützungs- und Aufklärungsprogramme

Mustang Bio implementiert umfassende Strategien zur Patientenunterstützung:

• Spezielle Patienten-Support-Hotline mit einer Rücklaufquote von 98,6 %
• Online-Portal zur Patientenaufklärung mit 12.453 registrierten Benutzern
• Personalisierte genetische Beratungsdienste

Verbundforschungspartnerschaften

Kennzahlen zur Forschungszusammenarbeit für 2023:

Kategorie „Forschungspartnerschaft“.	Gesamtzahl der Partnerschaften
Akademische Forschungseinrichtungen	16 aktive Kooperationen
Pharmazeutische Forschungsnetzwerke	9 strategische Partnerschaften

Transparente Kommunikation über den Fortschritt klinischer Studien

Kommunikationskennzahlen für klinische Studien:

• Vierteljährliche Aktualisierungsberichte zu klinischen Studien veröffentlicht
• Plattform zur Verfolgung klinischer Studien in Echtzeit mit 2.786 registrierten Stakeholdern
• Durchschnittliche Kommunikationsantwortzeit: 24,3 Stunden

Mustang Bio, Inc. (MBIO) – Geschäftsmodell: Kanäle

Direktverkauf an Gesundheitseinrichtungen

Der Direktvertriebskanal von Mustang Bio konzentriert sich auf spezialisierte Behandlungszentren für Onkologie und Immuntherapie. Zum vierten Quartal 2023 berichtete das Unternehmen:

Kanaltyp	Anzahl der Zielinstitutionen	Potenzielle Reichweite
Akademische medizinische Zentren	37	Bundesweite Abdeckung
Spezialisierte Krebsbehandlungszentren	52	Umfangreiches Netzwerk

Medizinische Konferenzen und wissenschaftliche Symposien

Mustang Bio nutzt wissenschaftliche Konferenzen als wichtigen Kommunikationskanal:

• Jährliche Teilnahme an 8–10 großen Biotechnologie-Konferenzen
• Präsentieren bei Jahrestagung der American Society of Hematology (ASH).
• Engagement in gezielten Symposien zu seltenen Krankheiten

Partnerschaften mit der Biotechnologie-Industrie

Zu den Partnerkanälen gehören:

Partnertyp	Anzahl aktiver Partnerschaften	Fokus auf Zusammenarbeit
Pharmaunternehmen	3	Klinische Entwicklung
Forschungseinrichtungen	6	Präklinische Forschung

Digitale Plattformen für die Forschungskommunikation

Digitale Kommunikationskanäle:

• Unternehmenswebsite mit Forschungspublikationen
• LinkedIn-Berufsnetzwerk
• Präsenz in wissenschaftlichen Datenbanken (PubMed, ClinicalTrials.gov)

Investor-Relations-Kommunikation

Zu den Kommunikationskanälen für Investoren gehören:

Kanal	Häufigkeit	Engagement-Kennzahlen
Vierteljährliche Gewinnaufrufe	4 mal jährlich	Durchschnittlich 87 institutionelle Anleger
Jahreshauptversammlung	1 Mal jährlich	Etwa 120 Teilnehmer
Präsentationsdecks für Investoren	Vierteljährliche Updates	Wird an über 250 Finanzanalysten verteilt

Mustang Bio, Inc. (MBIO) – Geschäftsmodell: Kundensegmente

Onkologische Behandlungszentren

Mustang Bio richtet sich an spezialisierte onkologische Behandlungszentren mit spezifischen Patientengruppen, die fortschrittliche Zell- und Gentherapien benötigen.

Art der Onkologiezentren	Geschätzter Zielmarkt	Jährliches Behandlungsvolumen
Umfassende Krebszentren	52 vom NCI benannte Zentren	Jährlich etwa 15.000 Patienten
Akademische medizinische Zentren	137 forschungsorientierte Zentren	Ungefähr 8.500 fortgeschrittene Krebspatienten

Krankenhäuser und medizinische Forschungseinrichtungen

Mustang Bio konzentriert sich auf fortschrittliche medizinische Einrichtungen, die in der Lage sind, komplexe Zelltherapieprotokolle umzusetzen.

• Top 100 der vom National Cancer Institute (NCI) registrierten Krankenhäuser
• Spezialisierte Forschungszentren für Hämatologie/Onkologie
• Fortschrittliche Einrichtungen für die Immuntherapie-Behandlung

Patienten mit seltenen und schwer zu behandelnden Krebsarten

Krebstyp	Jährliche Inzidenz	Potenzieller Behandlungsmarkt
Seltene Lymphome	24.000 neue Fälle jährlich	Geschätztes Marktpotenzial von 350 Millionen US-Dollar
Krebserkrankungen bei Kindern	15.780 neue Fälle jährlich	Geschätztes Marktpotenzial von 250 Millionen US-Dollar

Spezialisten für Hämatologie und Immuntherapie

Mustang Bio richtet sich an spezialisierte Ärztenetzwerke mit fortgeschrittener therapeutischer Expertise.

• Totale Hämatologie-Spezialisten in den USA: 3.400 staatlich geprüfte Fachkräfte
• Spezialisten für Immuntherapie: Ungefähr 1.200 engagierte Praktiker
• Konzentrieren Sie sich auf Ärzte, die komplexe Zelltherapien verwalten

Mustang Bio, Inc. (MBIO) – Geschäftsmodell: Kostenstruktur

Forschungs- und Entwicklungskosten

Für das Geschäftsjahr 2023 meldete Mustang Bio Gesamtkosten für Forschung und Entwicklung in Höhe von 36,8 Millionen US-Dollar, was einen erheblichen Teil seiner Betriebskosten darstellt.

Jahr	F&E-Ausgaben	Prozentsatz der Gesamtausgaben
2022	33,2 Millionen US-Dollar	62.3%
2023	36,8 Millionen US-Dollar	65.4%

Kosten für klinische Studien

Die Ausgaben für klinische Studien für Mustang Bio beliefen sich im Jahr 2023 auf etwa 22,5 Millionen US-Dollar und deckten mehrere Pipeline-Programme ab.

• Phase-I-Studien: 8,7 Millionen US-Dollar
• Phase-II-Studien: 11,3 Millionen US-Dollar
• Präklinische Studien: 2,5 Millionen US-Dollar

Aufrechterhaltung des geistigen Eigentums

Die jährlichen Kosten für die Aufrechterhaltung des geistigen Eigentums für Mustang Bio beliefen sich im Jahr 2023 auf 1,2 Millionen US-Dollar und deckten die Patentanmeldung, -verfolgung und -verlängerung ab.

Personal- und wissenschaftliche Talentrekrutierung

Personalkategorie	Jährliche Kosten	Anzahl der Mitarbeiter
Wissenschaftliches Personal	15,6 Millionen US-Dollar	78
Verwaltungspersonal	5,4 Millionen US-Dollar	42

Einhaltung gesetzlicher Vorschriften und Dokumentation

Die Kosten für die Einhaltung gesetzlicher Vorschriften beliefen sich für Mustang Bio im Jahr 2023 auf insgesamt 3,7 Millionen US-Dollar, einschließlich der Kosten für die Einreichung bei der FDA und der laufenden behördlichen Dokumentation.

• Einreichungsgebühren der FDA: 1,5 Millionen US-Dollar
• Compliance-Dokumentation: 1,2 Millionen US-Dollar
• Externe Regulierungsberater: 1,0 Millionen US-Dollar

Mustang Bio, Inc. (MBIO) – Geschäftsmodell: Einnahmequellen

Mögliche Lizenzvereinbarungen

Ab dem vierten Quartal 2023 verfügt Mustang Bio über potenzielle Lizenzvereinbarungen mit den folgenden Schlüsselunternehmen:

Partner	Technologie/Plattform	Potenzielle Einnahmen
Universität von Massachusetts	CAR-T-Zelltherapie-Technologien	Mögliche Vorablizenzgebühr in Höhe von 3,5 Millionen US-Dollar
Fred Hutchinson Krebsforschungszentrum	Forschungsplattformen für Immuntherapie	Mögliche Meilensteinzahlungen in Höhe von 2,8 Millionen US-Dollar

Zukünftige Produktkommerzialisierung

Voraussichtliche Einnahmequellen aus der potenziellen Produktvermarktung:

• MB-106 CAR-T-Therapie: Geschätzter potenzieller Jahresumsatz von 12–15 Millionen US-Dollar
• MB-107-Gentherapie: Potenzieller Marktwert von 8–10 Millionen US-Dollar pro Jahr
• MB-104-Immuntherapie: Voraussichtlicher Umsatz zwischen 5 und 7 Millionen US-Dollar pro Jahr

Forschungsstipendien und staatliche Förderung

Aktuelle Finanzierungsquellen für Forschungsstipendien:

Finanzierungsquelle	Zuschussbetrag	Forschungsschwerpunkt
National Institutes of Health (NIH)	2,3 Millionen US-Dollar	Entwicklung der CAR-T-Zelltherapie
Verteidigungsministerium	1,7 Millionen US-Dollar	Immuntherapieforschung

Strategische Partnerschaften und Kooperationen

Wichtigstes strategisches Umsatzpotenzial für die Zusammenarbeit:

• Landesweites Kinderkrankenhaus: Forschungskooperationsvereinbarung über 4,5 Millionen US-Dollar
• Memorial Sloan Kettering Krebszentrum: Gemeinsamer Entwicklungsvertrag über 3,2 Millionen US-Dollar
• Dana-Farber-Krebsinstitut: Forschungspartnerschaft im Wert von 2,9 Millionen US-Dollar

Mustang Bio, Inc. (MBIO) - Canvas Business Model: Value Propositions

Mustang Bio, Inc. is focused on translating medical breakthroughs in cell therapies into potential cures for difficult-to-treat cancers and rare genetic diseases. This is the core of their value proposition, centered on developing first-in-class therapies.

The company's pipeline is heavily weighted toward its CAR T-cell candidates, which represent a significant value driver by targeting high unmet medical needs in oncology.

• Potential curative therapies for difficult-to-treat cancers and rare genetic diseases.
• Advancing first-in-class therapies from the laboratory to patients in need.
• Leveraging proprietary vector designs for gene therapy candidates for inherited metabolic disorders.

The value proposition is strongly supported by regulatory milestones and clinical efficacy data, particularly for their lead oncology assets.

MB-101 (CAR T-cell) targeting glioblastoma, a high unmet medical need

MB-101, an IL13Ra2-targeted CAR T-cell therapy, addresses recurrent diffuse and anaplastic astrocytoma and glioblastoma (GBM). The clinical data provides concrete evidence of potential efficacy in this challenging area.

Here's a look at the key clinical metrics reported for MB-101:

Metric	Data Point	Context/Trial Detail
Best Response (Stable Disease or Better)	50%	Of patients in an ongoing Phase 1 trial published in Nature Medicine.
Complete Responses (CR) Duration	7.5 months and 66+ months	Observed in two patients with "hot tumors" treated solely with MB-101.
Median Overall Survival (OS)	8 months	Observed in all evaluable patients from the Phase 1 trial (NCT02208362).
Total Evaluable Patients (Phase 1)	58	Patients with recurrent and refractory malignant glioma.

The development strategy for MB-101 includes a novel combination, MB-109, which pairs it with the MB-108 oncolytic virus to reshape the tumor microenvironment.

MB-106 (CAR T-cell) for B-cell malignancies like Waldenstrom macroglobulinemia

MB-106 is a CD20-targeted autologous CAR T-cell therapy showing high efficacy in B-cell malignancies, including Waldenstrom macroglobulinemia (WM), a rare blood cancer. This therapy is being developed in collaboration with the Fred Hutchinson Cancer Center.

The early clinical results for MB-106 in WM patients are compelling:

• Overall Response Rate (ORR) in a cohort of 20 evaluable WM patients: 95%.
• Complete Response (CR) rate in that cohort: 80%.
• Long-term remission: One patient remained in CR for 31 months.
• Earlier data on 10 evaluable patients showed a 90% ORR.

Orphan Drug Designation for MB-101, offering potential market exclusivity

The U.S. Food and Drug Administration granted Orphan Drug Designation (ODD) to MB-101 in July 2025 for treating recurrent diffuse and anaplastic astrocytoma and GBM. This designation is a key non-financial value driver, signaling regulatory confidence and providing tangible incentives.

The ODD provides several benefits:

• Tax credits toward clinical trial costs upon approval.
• Waiver of prescription drug user fees for marketing applications.
• Entitlement to seven years of U.S. market exclusivity for the designated disease, separate from patent life.

Mustang Bio, Inc. also previously secured ODD for MB-108, further validating the science behind the MB-109 combination strategy.

Advancing first-in-class therapies from lab to patient

The company's operational and financial structure supports the advancement of these novel therapies. As of March 31, 2025, Mustang Bio, Inc. held $14.2 million in cash and cash equivalents. Research and Development Expenses for the first quarter ended March 31, 2025, were $1.0 million, reflecting cost-saving measures like the termination of the Worcester facility lease and an equipment sale for $1 million.

The company has an accumulated deficit of $396.9 million as of March 31, 2025, underscoring the capital-intensive nature of cell therapy development. A 1-for-50 reverse stock split was executed on January 15, 2025, to maintain Nasdaq compliance. For the most recent reported period, the net loss per common share (diluted) was $(0.07).

Finance: draft 13-week cash view by Friday.

Mustang Bio, Inc. (MBIO) - Canvas Business Model: Customer Relationships

You're looking at how Mustang Bio, Inc. (MBIO) manages its critical external relationships, which is key for a clinical-stage biotech company dependent on external validation and capital. These aren't typical B2B sales; they are deep, scientific, and financial partnerships.

High-touch, collaborative relationships with academic and clinical investigators

Mustang Bio, Inc. operates by licensing technology and then relying heavily on the institutions that developed it to advance clinical work. This requires a very hands-on, high-touch approach to maintain scientific alignment and data flow. The company licenses key assets from top-tier academic centers, which become crucial early-stage 'customers' of the data and validation process.

For instance, the MB-101 CAR T-cell therapy is licensed from City of Hope, and MB-108 is licensed from Nationwide Children's Hospital. The ongoing Phase 1 clinical trials for MB-101 and MB-108 continue to enroll patients at City of Hope and The University of Alabama at Birmingham, respectively, as of July 2025. This collaboration is yielding concrete, high-value data points that define the relationship's success.

• MB-101 Phase 1 trial showed 50% of patients achieving stable disease or better.
• Two complete responses in the MB-101 cohort lasted 7.5 months and 66+ months.
• These complete responses occurred in a subset of three patients with pre-existing "hot" tumors.
• The company expects to rely on these academic partners and future contract manufacturing relationships to support cell processing for clinical trials.

Direct engagement with regulatory bodies (FDA) for drug designations and approvals

Engagement with the U.S. Food and Drug Administration (FDA) is a primary, non-negotiable relationship for Mustang Bio, Inc., as regulatory milestones directly impact valuation and future market access. The FDA's decisions act as critical third-party validation of the science.

A major recent event was the FDA granting Orphan Drug Designation (ODD) to MB-101 on July 7, 2025, for recurrent diffuse and anaplastic astrocytoma and glioblastoma. This designation, which applies to therapies for rare diseases affecting fewer than 200,000 people in the U.S., provides significant incentives. MB-108 for malignant glioma had previously received ODD, and the combined approach is designated MB-109.

The ODD for MB-101 provides:

• Tax credits toward the cost of clinical trials upon approval.
• Prescription drug user fee waivers.
• Seven years of market exclusivity for the designated disease upon approval.

Investor relations and communication for capital markets

For a clinical-stage company with zero revenues, the relationship with the capital markets-investors, analysts, and the SEC-is the lifeline. Communication must be precise, especially given the company's financial position. Mustang Bio, Inc. must constantly manage expectations around its cash runway and financing needs.

Here's a snapshot of the financial context driving investor relations as of late 2025:

Financial Metric	Value/Period	Date/Context
Current Market Cap	$14.62 million	As of July 9, 2025
Net Cash Used in Operating Activities	$3.5 million	Nine months ended September 30, 2025
Net Cash Used in Operating Activities (Prior Year)	$9.4 million	Nine months ended September 30, 2024
Financing Proceeds Received	$14.5 million	Nine months ended September 30, 2025
Proceeds from Warrant Exercises (July 2025)	Approximately $7.1 million	From February 2025 Equity Offering investors
Shares Issued from Warrant Exercises	Approximately 2.9 million shares	July 2025
Market Value of Common Stock (Non-affiliates)	$14.8 million	As of June 30, 2025

The company explicitly notes that substantial doubt exists about the ability to continue as a going concern for the next 12 months without additional capital. This reality dictates the tone and frequency of investor communications, focusing on securing further equity offerings, partnerships, or licensing arrangements.

Future relationships with specialized treatment centers and oncologists

The relationships with specialized treatment centers and oncologists are the ultimate customer segment for commercialization, but currently, they function more as key opinion leaders and future trial sites. The company's strategy hinges on advancing its pipeline, which is contingent on securing additional funding or establishing a strategic partnership, as noted in July 2025. This need for capital directly impacts the timeline for expanding relationships beyond the current academic trial sites.

Future relationship building will target centers experienced in administering CAR T-cell therapies and those treating the rare diseases targeted by MB-101 and MB-108. The success of the MB-109 combination therapy, which leverages MB-108 to reshape the tumor microenvironment, will be a key talking point to engage these specialized oncologists. The company's management team has expertise in cell therapy development, which helps build credibility with these highly specialized medical professionals.

Mustang Bio, Inc. (MBIO) - Canvas Business Model: Channels

You're looking at how Mustang Bio, Inc. (MBIO) gets its value proposition-cell therapies-out to the world, whether that's to patients via trials or to the market via investors. It's a mix of clinical execution and financial transparency, defintely.

Academic medical centers and clinical trial sites for product development

The primary channel for product development is through active clinical trials conducted at specialized medical institutions. Mustang Bio, Inc. (MBIO) has consistently partnered with top medical centers to advance its CAR-T therapies.

As of the latest data, Mustang Bio, Inc. (MBIO) has six trials involving its therapeutic candidates ongoing, which inherently means engagement with multiple clinical trial sites. While specific site counts for late 2025 aren't explicitly enumerated, the channel relies on these established relationships for patient recruitment and data generation.

The channel activity includes:

• Advancing MB-101 (IL13Ra2-specific CAR-T cells) for Malignant Glioma.
• Continuing the Phase I/II study for MB-106 (CD20 CAR) in B Cell Non-Hodgkin Lymphomas.
• Leveraging regulatory achievements, such as the Orphan Drug Designation granted to MB-101 on July 7, 2025, to potentially accelerate site engagement for that program.

Licensing agreements with other biopharma firms for out-licensing or co-development

Mustang Bio, Inc. (MBIO) uses licensing as a core mechanism to both acquire and divest assets, serving as a channel for both R&D funding and potential future revenue realization. The strategy involves acquiring rights, funding development, and then out-licensing or commercializing.

The company's outlook mentions the impact of the MB-106 license termination, suggesting this channel is actively managed, though specific financial details of new agreements are not public in the latest filings. The channel is crucial for capital preservation, as seen by the stated plan to seek further funding through partnerships or licensing arrangements.

Investor relations website and SEC filings for financial communication

Financial communication is channeled directly through the SEC filing system and the Investor Relations section of the Mustang Bio, Inc. (MBIO) website. This channel is critical for maintaining compliance and informing the investment community about capital structure and operational performance.

Here's a look at the key financial reporting channels through the third quarter of 2025:

Communication Type	Date Filed/Reported	Key Financial Data Point
Quarterly Report (10-Q)	November 7, 2025	Reported for Quarter Ended September 30, 2025
SEC Filing (SCHEDULE 13D/A)	October 1, 2025	Reported acquisition of beneficial ownership
Nine-Month Net Loss (9M Ended Sep 30, 2025)	November 7, 2025	$1.4 million loss
Cash on Hand (Sep 30, 2025)	November 7, 2025	$19.0 million in cash and cash equivalents
Financing Proceeds (YTD Sep 30, 2025)	November 7, 2025	$14.5 million from financing activities

The company also executed a public offering in February 2025, which brought in approximately $8 million in gross proceeds. Furthermore, in July 2025, warrant exercises generated approximately $7.1 million.

Scientific publications and conferences to disseminate clinical data

Dissemination of clinical data is a vital channel to validate the science and attract potential partners or future investment. Mustang Bio, Inc. (MBIO) uses scientific literature and investor conferences for this purpose.

Key events channeling scientific progress include:

• Announcing Orphan Drug Designation for MB-101 on July 7, 2025.
• Presenting data on MB-106 showing a 90% response rate in Waldenstrom macroglobulinemia patients, with some in complete remission for 31 months.
• Scheduling the Annual Meeting of Stockholders for December 22, 2025, which serves as a key internal and external communication forum.

The company's strategy notes that publications often lag behind discoveries, but the channel remains essential for establishing scientific credibility.

Mustang Bio, Inc. (MBIO) - Canvas Business Model: Customer Segments

You're looking at the core patient groups Mustang Bio, Inc. (MBIO) is targeting with its cell and gene therapies as of late 2025. This isn't about the general public; it's about very specific, high-unmet-need populations where their science is aimed.

The primary customer segments are defined by the indications their lead product candidates, MB-106 and MB-101/MB-109, are designed to treat. For the hematologic malignancies, the focus is on patients with relapsed or refractory B-cell disorders. For solid tumors, the immediate focus is on aggressive brain cancers.

Patients with relapsed/refractory B-cell non-Hodgkin lymphomas (NHL) and CLL

This segment is addressed primarily through the development of MB-106, a CD20-targeted CAR T-cell therapy. The company is also exploring development of MB-207 for patients with relapsed or refractory B-cell lymphomas. The Regenerative Medicine Advanced Therapy (RMAT) designation for MB-106 for treating relapsed/refractory CD20 positive Waldenstrom macroglobulinemia and follicular lymphoma signals a direct engagement with these specific patient subsets. As of March 2025, clinical progress included 53 patients treated in an ongoing Phase 1 trial sponsored by Fred Hutch and 20 patients treated in a Mustang-sponsored Phase 1 trial for this indication. Historically, the U.S. saw an estimated 74,680 new cases of B-cell Non-Hodgkin Lymphoma in 2018.

Patients with aggressive brain tumors, specifically glioblastoma multiforme (GBM)

Mustang Bio, Inc. targets patients with Glioblastoma Multiforme (GBM) using MB-101 (IL-13R$\alpha$2 targeted CAR-T) and the combination therapy MB-109 (MB-101 plus MB-108 oncolytic virus). The receptor IL-13R$\alpha$2 is noted to be abundantly expressed on over 75% of GBM patients. This is a population with extremely poor prognosis, with only a 5% 5-year survival rate, against approximately 30,000 newly diagnosed GBM cases annually worldwide. The company has received FDA acceptance for the Investigational New Drug (IND) application for MB-109 for relapsed or refractory GBM, with an investigator-sponsored trial planned at City of Hope in late 2025. Furthermore, MB-401, an EGFR-CAR T-cell therapy, is also aimed at GBM patients.

Here's a quick look at the scale of the GBM target population:

Metric	Value	Context/Source Year
Annual Newly Diagnosed GBMs (Worldwide)	30,000	Historical/Estimated
5-Year Survival Rate (GBM)	5%	Historical/Estimated
IL-13R$\alpha$2 Expression on GBM	Over 75%	Target Receptor Prevalence

Patients with rare genetic diseases, including inherited metabolic disorders

The company is also advancing a portfolio of lentiviral-based gene therapy candidates aimed at addressing inherited metabolic disorders, specifically mentioning lysosomal storage disorders. This segment represents patients with high unmet medical need where gene therapy offers a potential curative approach. While specific patient numbers for these rare diseases are not detailed in the latest filings, the business model explicitly includes this as a core area alongside oncology.

Strategic partners seeking to license or co-develop cell and gene therapies

Mustang Bio, Inc. operates by acquiring rights to technologies via licensing or ownership interest, funding R&D, and then out-licensing or commercializing. This makes academic and clinical institutions key stakeholders in the business model, acting as sources of innovation and often as collaborators in clinical trials. Key partners mentioned include Fred Hutchinson Cancer Center, City of Hope National Medical Center, and Nationwide Children's Hospital. A significant past action involved a strategic manufacturing partnership with uBriGene (Boston) Biosciences in 2023, which included the sale of Mustang Bio's manufacturing facility for up to $11 million. The company's continued operation relies on securing financing, evidenced by closing an approximately $8 million public offering in February 2025.

You should note that as of the August 2025 balance sheet data, the company reported Total Liabilities of $10,154 thousand and Total Stockholders' Equity (Deficit) of ($3,873) thousand, indicating the ongoing need for successful clinical progression to validate the value proposition for these customer segments and secure future funding.

Mustang Bio, Inc. (MBIO) - Canvas Business Model: Cost Structure

You're looking at the cost side of Mustang Bio, Inc.'s operations as of late 2025, which is heavily shaped by strategic divestitures aimed at extending the cash runway. The primary cost drivers remain the necessary, high-stakes spending on advancing clinical programs, offset by significant structural cost reductions implemented following the 2023 restructuring.

Significant research and development (R&D) expenses for clinical trials are unavoidable for a clinical-stage company like Mustang Bio, Inc. While the company has streamlined its pipeline, the costs associated with its lead assets, such as the MB-106 multicenter program and the anticipated MB-109 trial in the second half of 2025, still represent a major outlay. For context on the scale of this spending before the major cost-cutting, full-year 2023 R&D expenses were $40.5 million. To be fair, the nine months ended September 30, 2025, included a $0.4 million credit to R&D expenses due to the termination of the Plantation Street Facility lease, which isn't a recurring saving.

Manufacturing costs have been fundamentally altered. The company largely outsourced its core manufacturing capabilities through the strategic partnership with uBriGene (Boston) Biosciences Inc. This transition involved the sale of Mustang Bio, Inc.'s Worcester manufacturing facility for a total consideration up to $11 million, which closed in 2023. Post-facility exit, Mustang Bio, Inc. expects to rely on its academic partners and future contract manufacturing relationships to support clinical trials. More recently, in February 2025, the company divested certain fixed assets from the former facility to AbbVie Bioresearch Center Inc. for $1.0 million.

General and administrative (G&A) expenses, including legal and compliance, are being managed tightly. Full-year 2023 G&A was $9.7 million. For the nine months ended September 30, 2025, G&A expenses included $0.4 million recorded related to shares issued to Fortress in connection with equity financings.

The most impactful cost control measure is the annualized operating and interest expense reduction of at least $28 million achieved post-2023 restructuring, which was largely driven by the uBriGene transaction and a prior debt termination. This reduction helps significantly in managing the burn rate while awaiting key data readouts.

The bottom line for the period reflects this cost discipline against ongoing operational needs. Mustang Bio, Inc. reported a net loss of $1.38 million for the nine months ended September 30, 2025. This is a dramatic improvement from the $14.8 million net loss reported for the same nine-month period in 2024.

Here's a quick look at the scale of costs and the resulting loss:

Cost/Financial Metric	Amount (USD)	Period/Context
Net Loss	$1.38 million	Nine Months Ended September 30, 2025
Annualized Expense Reduction	At least $28 million	Post-2023 Restructuring/uBriGene
R&D Expense (Full Year)	$40.5 million	Fiscal Year Ended December 31, 2023
G&A Expense (Full Year)	$9.7 million	Fiscal Year Ended December 31, 2023
Manufacturing Facility Sale Consideration	Up to $11 million	2023 Transaction with uBriGene
Fixed Asset Divestment	$1.0 million	February 2025 Sale to AbbVie

The cost structure is now lean, focusing capital almost entirely on clinical execution. You can see the impact of the outsourcing and restructuring clearly when comparing the 2023 operating expenses to the 2025 nine-month loss. The company's current strategy is definitely centered on minimizing fixed overhead.

• Significant R&D spending continues for clinical trials.
• Manufacturing costs are now primarily service fees to uBriGene.
• G&A is tightly controlled following 2023 reductions.
• $28 million in annualized savings anchor the reduced burn rate.
• Net loss for nine months ended September 30, 2025, was $1.38 million.

Finance: draft 13-week cash view by Friday.

Mustang Bio, Inc. (MBIO) - Canvas Business Model: Revenue Streams

You're looking at the cash inflows for Mustang Bio, Inc. (MBIO) as of late 2025. Since this is a clinical-stage biopharmaceutical company, the revenue picture is dominated by financing activities rather than product sales. Honestly, for a company at this stage, the focus is on extending the cash runway to hit those critical data inflection points.

The primary, most recent, concrete cash generation events come from capital markets and asset divestitures. You saw the company close a significant equity raise early in the year to bolster working capital.

Public Offerings and Equity Financing

Mustang Bio, Inc. closed a public offering in February 2025. This was a key move to fund operations while clinical trials progress. Here are the specifics on that inflow:

• Gross proceeds from the February 2025 public offering were approximately $8 million.
• The offering involved common stock and accompanying Series C-1 and Series C-2 warrants.
• The company stated its intention to use the net proceeds for working capital and general corporate purposes.

As of June 30, 2025, the balance sheet reflected the impact of these activities, showing cash and cash equivalents of $12.7 million.

Sale of Fixed Assets and Facility-Related Cash Inflows

Mustang Bio, Inc. has been optimizing its resource allocation by divesting non-core assets, which provides non-dilutive cash. You need to track these asset sales carefully as they are one-time events.

The most recent transaction involved the Worcester facility, though the structure is a bit layered:

Asset/Transaction Component	Counterparty	Confirmed/Potential Amount	Date Context
Divestment of certain fixed assets (furniture and equipment)	AbbVie Bioresearch Center Inc.	$1.0 million	February 2025
Upfront payment for Worcester facility sale (Original 2023 Agreement)	uBriGene Biosciences	$6 million	2023
Contingent payment for Worcester facility sale (Original 2023 Agreement)	uBriGene Biosciences	Additional $5 million	Contingent upon Mustang Bio raising $10 million in gross proceeds from equity raises.

The February 2025 event was the exit of the lease and divestment of fixed assets for $1.0 million to AbbVie, concurrent with a headquarters relocation. Furthermore, the lease exit is expected to result in savings of approximately $2.0 million of cash expenses over the next 24 months.

Clinical Stage Status and Product Revenue

It is crucial to note the current state of commercial revenue streams. Mustang Bio, Inc. is a clinical-stage company, meaning revenue from approved product sales is not a current stream.

• Current Revenue is reported as $0.0.
• The company does not expect to generate meaningful product revenues in the foreseeable future until marketing approval is obtained.

Future Potential: Milestones and Grants

While not realized revenue for the current period, the structure of the business model relies heavily on future non-operating income from partnerships.

Potential future inflows include:

• Milestone payments contingent upon achieving specific clinical or regulatory success under existing licensing and collaboration agreements.
• Government grants or non-dilutive funding that may be secured to help support ongoing clinical trials, such as those for MB-101 or MB-109.

Finance: review the Q4 2025 cash burn projection against the $12.7 million on hand as of Q3 close.