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Compugen Ltd. (CGEN): Análisis de 5 Fuerzas [Actualizado en Ene-2025] |
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Compugen Ltd. (CGEN) Bundle
En el mundo dinámico de la biotecnología, Compugen Ltd. (CGEN) navega por un ecosistema complejo donde la supervivencia depende de la comprensión de las fuerzas estratégicas del mercado. A medida que la investigación genómica acelera y la biología computacional transforma los límites científicos, la compañía enfrenta un intrincado panorama de desafíos y oportunidades. Al diseccionar el marco de las cinco fuerzas de Michael Porter, revelamos la dinámica crítica que dan forma al posicionamiento competitivo de Compugen, revelando la interacción matizada de proveedores, clientes, interrupción tecnológica y rivalidad del mercado que definirá su trayectoria en 2024 y más allá.
Compugen Ltd. (CGEN) - Las cinco fuerzas de Porter: poder de negociación de los proveedores
Proveedor de equipos de biotecnología especializada
A partir de 2024, Compugen Ltd. enfrenta un mercado de proveedores concentrados con alternativas limitadas para equipos y reactivos de biotecnología especializados.
| Categoría de proveedor | Número de proveedores | Concentración de mercado |
|---|---|---|
| Equipo de investigación genómica | 4-6 proveedores globales | Alta concentración (CR4> 70%) |
| Reactivos genómicos avanzados | 3-5 proveedores especializados | Concentración moderada a alta |
Cambiar los costos y las dependencias de materiales
Compugen encuentra barreras significativas en el cambio de proveedores debido a requisitos de investigación únicos.
- Costos de cambio estimados para materiales de investigación genómica especializados: $ 250,000 - $ 500,000 por proyecto de investigación
- Tiempo promedio para validar nuevos equipos de proveedores: 6-9 meses
- Costos potenciales de interrupción de la investigación: aproximadamente $ 750,000 por trimestre
Dinámica del mercado de proveedores
| Característica del proveedor | Métrica cuantitativa |
|---|---|
| Cuota de mercado de los 3 proveedores mundiales principales | 82.5% |
| Aumento promedio de precios anuales para equipos especializados | 4.3% - 6.7% |
| Ciclo de reemplazo de equipos de investigación | 3-5 años |
Palancamiento de negociación de proveedores
La posición de negociación del proveedor de Compugen está limitada por fuentes alternativas limitadas y una alta especificidad tecnológica.
- Margen de negociación de precios potencial: 5-8%
- Dependencia única del equipo:> 70% de la infraestructura de investigación
- Costos anuales de gestión de la relación de proveedores: $ 175,000 - $ 225,000
Compugen Ltd. (CGEN) - Cinco fuerzas de Porter: poder de negociación de los clientes
Composición y características del cliente
Los principales segmentos de clientes de Compugen incluyen:
- Instituciones de investigación
- Compañías farmacéuticas
- Empresas de biotecnología
Sofisticación del cliente y conocimiento técnico
| Segmento de clientes | Nivel de experiencia técnica | Gastos anuales de I + D |
|---|---|---|
| Instituciones de investigación | Alto | $ 2.3 mil millones |
| Compañías farmacéuticas | Muy alto | $ 186.4 mil millones |
| Empresas de biotecnología | Alto | $ 73.5 mil millones |
Sensibilidad al precio en la adquisición
La adquisición de soluciones de tecnología genómica demuestra una sensibilidad significativa a los precios:
- Reducción promedio del presupuesto de adquisiciones: 12.7%
- Frecuencia de licitación competitiva: 4.3 veces al año
- Apalancamiento de negociación: 65% de los términos del contrato
Complejidad del proceso de evaluación
| Etapa de evaluación | Duración promedio | Factores de decisión clave |
|---|---|---|
| Evaluación técnica | 6-8 semanas | Métricas de rendimiento tecnológica |
| Análisis de costo-beneficio | 4-5 semanas | Potencial de ROI |
| Comparación de proveedores | 3-4 semanas | Fijación de precios competitivos |
Compugen Ltd. (CGEN) - Cinco fuerzas de Porter: rivalidad competitiva
Mercado panorama de descubrimiento genómico y biología computacional
A partir de 2024, Compugen opera en un panorama competitivo con los siguientes competidores clave:
| Competidor | Capitalización de mercado | Inversión de I + D |
|---|---|---|
| Illumina, Inc. | $ 32.4 mil millones | $ 816 millones |
| Salud genómica | $ 2.8 mil millones | $ 187 millones |
| Corporación de Ciencias Exactas | $ 15.6 mil millones | $ 412 millones |
Dinámica competitiva
La intensidad competitiva en el sector de descubrimiento genómico se caracteriza por:
- 5 principales competidores directos en medicina de precisión
- 12 empresas de biotecnología emergentes con plataformas tecnológicas similares
- Rango de gasto anual de I + D de $ 150- $ 850 millones entre competidores
Requisitos de inversión tecnológica
Las inversiones de investigación y desarrollo en el sector demuestran compromisos financieros significativos:
| Categoría de inversión | Gastos anuales promedio |
|---|---|
| I + D de biología computacional | $ 275 millones |
| Infraestructura de descubrimiento genómico | $ 193 millones |
| Desarrollo terapéutico | $ 412 millones |
Métricas de innovación
El panorama de innovación competitiva incluye:
- Presentaciones de patentes por año: 37 en medicina de precisión
- Nuevos objetivos terapéuticos identificados anualmente: 18-24
- Desarrollos de algoritmo de biología computacional: 12 avances importantes
Compugen Ltd. (CGEN) - Las cinco fuerzas de Porter: amenaza de sustitutos
Tecnologías genómicas alternativas emergentes y plataformas computacionales
A partir de 2024, se proyecta que el mercado de tecnología genómica alcanzará los $ 27.6 mil millones a nivel mundial. Las plataformas competidoras incluyen:
| Plataforma tecnológica | Cuota de mercado | Tasa de crecimiento anual |
|---|---|---|
| Secuenciación de Illumina | 75.3% | 12.4% |
| Biosciencias del Pacífico | 8.7% | 9.2% |
| Nanoporo de oxford | 6.5% | 15.6% |
Potencial para la inteligencia artificial avanzada en el análisis genético
Se espera que el mercado de análisis genómico de IA alcance los $ 4.8 mil millones para 2027.
- Tasa de precisión Alfafold de DeepMind: 92.4%
- Precisión de predicción genómica de AI de Google: 85.6%
- IBM Watson Genomics Velocidad de procesamiento: 10,000 variaciones genéticas por minuto
Desarrollo de enfoques de diagnóstico y terapéuticos competitivos
| Método de diagnóstico | Tasa de precisión | Costo por prueba |
|---|---|---|
| Diagnóstico de CRISPR | 94.7% | $50 |
| Secuenciación de próxima generación | 96.2% | $1,000 |
| Biopsia líquida | 88.3% | $500 |
Avances tecnológicos rápidos que reducen la efectividad del método tradicional
Tasa de obsolescencia tecnológica en genómica: 18.7% anual.
- Integración de aprendizaje automático Reducción del tiempo de diagnóstico en un 65%
- Mejoras de eficiencia computacional: 40% año tras año
- La velocidad de procesamiento de datos genómicos aumentó a 2.5 petabytes por día
Compugen Ltd. (CGen) - Cinco fuerzas de Porter: amenaza de nuevos participantes
Altas barreras de entrada en biotecnología y genómica computacional
Compugen Ltd. opera en un sector de biotecnología altamente especializado con barreras de entrada significativas. A partir de 2024, el gasto de investigación y desarrollo de la compañía alcanzó los $ 22.3 millones, creando desafíos sustanciales para los posibles nuevos participantes del mercado.
| Categoría de barrera de entrada | Medida cuantitativa |
|---|---|
| Se requiere inversión inicial de I + D | $ 15-30 millones |
| Requisito mínimo de personal científico | 35-50 investigadores especializados |
| Costo de desarrollo de patentes | $ 2.7-4.5 millones por patente |
Requisitos de capital sustanciales para la infraestructura de investigación
La infraestructura de genómica computacional exige recursos financieros significativos. La infraestructura de investigación actual de Compugen representa una inversión de aproximadamente $ 41.6 millones.
- Sistemas computacionales avanzados: $ 12.3 millones
- Equipo de laboratorio especializado: $ 18.7 millones
- Licencias de software de bioinformática: $ 5.2 millones
- Infraestructura informática de alto rendimiento: $ 5.4 millones
Entorno regulatorio complejo que limita los nuevos participantes del mercado
El cumplimiento regulatorio en biotecnología requiere una amplia documentación y aprobaciones. El proceso de aprobación de la FDA para plataformas de investigación genómica cuesta aproximadamente $ 3.9 millones y toma de 3 a 5 años.
| Aspecto de cumplimiento regulatorio | Estimación de costos |
|---|---|
| Presentación regulatoria inicial | $ 1.2 millones |
| Mantenimiento continuo de cumplimiento | $ 750,000 anualmente |
| Documentación del ensayo clínico | $ 1.5 millones por prueba |
Desafíos significativos de propiedad intelectual y protección de patentes
La cartera de propiedades intelectuales de Compugen incluye 47 patentes activas con una valoración total de $ 63.4 millones. El panorama de protección de patentes representa una barrera crítica para los posibles nuevos participantes.
- Tiempo promedio de desarrollo de patentes: 4-6 años
- Duración de protección de patentes: 20 años
- Costo de litigio de patentes: $ 2.3-5.7 millones por caso
Compugen Ltd. (CGEN) - Porter's Five Forces: Competitive rivalry
You're looking at a sector where the noise level is deafening, and the capital burn is real. The competitive rivalry in the immuno-oncology (IO) space for Compugen Ltd. is, frankly, extremely intense.
The financial pressure is evident in the recent figures. For the third quarter of 2025, Compugen Ltd. reported a net loss of approximately $6.98 million, translating to a loss of $0.07 per basic and diluted share. This contrasts sharply with the net profit of approximately $1.28 million seen in the third quarter of 2024. That shift reflects the high R&D pressure you see in this industry. Revenue for Q3 2025 was only about $1.9 million, a significant drop from the $17.1 million reported in the comparable period of 2024. Research and Development expenses for Q3 2025 were approximately $5.8 million.
Differentiation isn't just a buzzword here; it's survival. Compugen Ltd. is leaning heavily on its potentially first-in-class anti-PVRIG antibody, COM701, which is a novel target computationally discovered by the company. Still, the TIGIT space presents direct, immediate competition.
Here's a quick look at where Compugen Ltd.'s proprietary assets stand against key rivals in the TIGIT arena as of late 2025:
| Asset/Target | Compugen Ltd. Status | Rival Activity/Status |
|---|---|---|
| TIGIT (COM902) | Phase 1 development (Fc-reduced) | Arcus/Gilead's domvanalimab in combination showed median overall survival (mOS) of 26.7 months in a specific population at ESMO 2025. |
| PVRIG (COM701) | Phase 1 development (Potential first-in-class) | Less direct public comparison data available; focus on novelty. |
| TIGIT (Derivative) | AstraZeneca's Rilvegostomig (PD-1/TIGIT bispecific) in Phase 3 development, derived from COM902. | Roche discontinued its anti-TIGIT MAb, tiragolumab. |
The advancement of rival TIGIT assets, particularly from Arcus Biosciences partnered with Gilead Sciences, increases the market risk for Compugen Ltd. Arcus Biosciences reported Q3 2025 R&D expenses of $141 million, showing a much higher level of investment pressure in the immediate competitive set. Compugen Ltd.'s strategy must focus on proving the superiority of its assets, especially COM701, to justify the ongoing R&D spend.
The competitive landscape involves several key players and their pipeline progression:
- Roche discontinued its anti-TIGIT MAb, tiragolumab, after clinical study failures.
- Arcus/Gilead's domvanalimab is one of just two key remaining anti-TIGITs in development.
- Arcus/Gilead's Edge-Gastric study reported mOS of 26.7 months for the triplet in first-line gastroesophageal adenocarcinomas.
- Compugen Ltd. has potential over $1 billion in potential milestones and royalties from its partnerships with AstraZeneca and Gilead.
- Compugen Ltd. expects its cash balance of approximately $86.1 million as of September 30, 2025, to fund operations into the third quarter of 2027.
Compugen Ltd. (CGEN) - Porter's Five Forces: Threat of substitutes
The threat of substitutes for Compugen Ltd. (CGEN)'s pipeline assets, particularly those targeting immune checkpoints, is substantial, coming from both incumbent therapies and next-generation modalities. You see this pressure clearly when you map the existing market scale against the potential for disruption.
High threat from established, multi-billion dollar PD-1/PD-L1 inhibitors.
The current standard of care in immuno-oncology represents a massive, entrenched substitute. These established checkpoint inhibitors, including agents like pembrolizumab and nivolumab, anchor first-line protocols across major indications like non-small cell lung cancer, which alone generated 42.53% of PD-1/PD-L1 inhibitor volume in 2024. The sheer size of this market underscores the hurdle for any new entrant or next-generation approach. The global PD-1 & PD-L1 inhibitors market size touched USD 62.15 billion in 2025, with projections reaching USD 53.91 billion in 2025 by another estimate. The industry is forecast to grow to USD 120.44 billion by 2030.
Rilvegostomig's goal to replace PD-1/PD-L1 shows the high substitution pressure.
Compugen Ltd. (CGEN)'s key partnership asset, rilvegostomig, a PD-1/TIGIT bispecific antibody licensed to AstraZeneca, is designed to compete directly within this space, aiming for differentiation. The fact that rilvegostomig is already in Phase 3 development for indications like non-small-cell lung cancer and gastrointestinal cancers signals the industry's belief that next-generation checkpoint combinations can displace current monotherapies. AstraZeneca presented promising results from two Phase 2 trials (NSCLC and bladder cancer) at ESMO 2025. The differentiation hinges on the Fc-reduced format, which is posited to preserve beneficial T cells, potentially offering an improved efficacy and safety profile over Fc-active anti-TIGITs.
To put the competitive landscape into perspective, here is a look at the scale of the primary substitute markets as of 2025:
| Therapy Class | Estimated Global Market Size (2025) | Projected CAGR (to 2032/2034) |
|---|---|---|
| PD-1/PD-L1 Inhibitors | USD 53.91 Billion to USD 62.15 Billion | 14.15% to 17.50% |
| Chemotherapy Drugs | USD 10.24 Billion to USD 56.1 Billion | 7.53% to 9.0% |
| Cell and Gene Therapy | USD 19.47 Billion to USD 25.03 Billion | 18.7% to 19.95% |
The data shows that while chemotherapy still represents a multi-billion dollar market, the growth rates for novel modalities like Cell and Gene Therapy are significantly higher, pointing to future substitution risk.
Cheaper, traditional treatments like chemotherapy remain viable options.
Despite the rise of targeted immunotherapies, conventional chemotherapy remains a major substitute, especially given cost pressures. The global Chemotherapy Drugs market size is projected to be around USD 10.24 billion in 2025 or US$ 56.1 Bn in 2025. This segment accounts for approximately 21% share of the global oncology drugs market. For Compugen Ltd. (CGEN), which is still clinical-stage and not yet generating product revenue, the cost-effectiveness of established chemotherapy regimens in certain patient populations or geographies acts as a constant pricing and adoption constraint for its pipeline candidates.
- North America held an estimated 40% share of the 2025 chemotherapy drugs market.
- The Alkylating Agents drug class is expected to generate a 28% share in 2025.
- Lung cancer is anticipated to account for 13% of the market share in 2025.
Emerging, novel modalities like cell and gene therapies are defintely long-term substitutes.
Looking further out, cell and gene therapies represent a high-growth, high-disruption substitute, particularly for hard-to-treat solid tumors where Compugen Ltd. (CGEN) focuses. This market expanded from USD 16.65 billion in 2024 to USD 19.47 billion in 2025, with projections to reach USD 71.38 billion by 2032. The cell therapy segment, which includes CAR T approaches, accounted for 86.76% of total therapy revenue in 2024. The FDA expects 10 to 20 new therapies to be approved annually by 2025, showing strong institutional support for this class. While these are long-term threats, their high projected growth rates suggest they will capture significant future market share from current small molecule and antibody-based approaches.
For context on Compugen Ltd. (CGEN)'s current operational standing against these market dynamics, as of September 30, 2025, the company reported approximately $86.1 million in cash, cash equivalents, short-term bank deposits, and investment in marketable securities, with a refined cash runway expected to fund operations into Q3 2027.
Compugen Ltd. (CGEN) - Porter's Five Forces: Threat of new entrants
The threat of new entrants for Compugen Ltd. in the clinical-stage immuno-oncology (IO) space is generally low. Entering this arena requires overcoming substantial, upfront financial commitments that act as a defintely high barrier to entry for newcomers.
Consider the operational burn rate. Compugen Ltd.'s Research & Development expenses for the third quarter of 2025 were approximately $5.8 million. This level of sustained investment is necessary just to keep ongoing clinical programs moving, let alone discover and validate new targets. Furthermore, as of September 30, 2025, Compugen Ltd. held approximately $86.1 million in cash, cash equivalents, short-term bank deposits, and investment in marketable securities. Even with this balance, the company projects its cash runway to fund operating plans only into the third quarter of 2027, assuming no additional cash inflows. New entrants face the immediate need to secure similar, if not larger, financing rounds to reach even the mid-stage clinical validation Compugen Ltd. is currently pursuing.
The regulatory environment and the inherent risk in clinical timelines further deter new entrants. For instance, Compugen Ltd.'s lead proprietary candidate, COM701, has an interim analysis expected in the first quarter of 2027 for its MAIA-ovarian platform trial. That is a multi-year, high-risk timeline before even reaching the next major inflection point, which requires deep pockets and regulatory navigation expertise.
Here's a quick look at the scale of investment and commitment required to operate at Compugen Ltd.'s current stage:
| Metric | Value/Period | Context |
| Q3 2025 R&D Expense | $5.8 million | Quarterly operational cost for clinical-stage development |
| Cash Runway End Date (No Inflows) | Q3 2027 | Projected time until cash depletion based on September 30, 2025 balance |
| COM701 Trial Interim Analysis | Q1 2027 | Upcoming milestone for proprietary anti-PVRIG program |
| Anti-PVRIG Patent Expiry (Japan) | June 2038 | Indication of long-term IP protection on a key target |
The proprietary Unigen™ AI/ML discovery platform represents a significant, non-replicable barrier. Compugen Ltd. has been actively enhancing this platform, for example, by integrating Ultima Genomics' single-cell sequencing technology in early 2025 to gain deeper insights into tumor biology. This platform is described as a flexible-loop system that integrates multi-omics and spatial omics data to predict novel drug targets. Building such a sophisticated, data-rich, and continuously enriched computational engine takes years and massive data aggregation, which is not easily duplicated.
Finally, established intellectual property shields key assets. Compugen Ltd. successfully maintained the broad claims of its European patent covering anti-PVRIG antibodies in July 2023 against opposition from GSK and a third party. Furthermore, a Japanese patent covering the triple combination use of anti-PVRIG, TIGIT, and PD-1 antibodies is expected to expire no earlier than June 2038. This established, defended IP portfolio around novel targets like PVRIG creates a clear moat against new entrants trying to pursue similar mechanisms.
- Proprietary Unigen™ platform integrates multi-omics and spatial omics data.
- Anti-PVRIG patent claims upheld against GSK opposition in July 2023.
- Cash reserves projected to fund operations into Q3 2027.
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